About

It took seven years to make a two ounce shot

Most of that was spent being wrong.

Dr. Howard Robins laughing during a speaking engagement, in front of a Science of Human Optimization banner.
Dr. Howard Robins speaking at the Science of Human Optimization Seminar
Dr. Howard Robins in headphones at a microphone, recording a podcast in front of a Doctor's Biome banner.
Dr. Howard Robins on his weekly podcast, discussing probiotic cultures

It started with a product people couldn’t get enough of

Dr. Howard Robins had been recommending living cultures to his patients for years. There was one product like it, made on Long Island, and it sold so well the maker couldn’t keep it in stock.

It was also being made without real controls. Batches were unpredictable. Bottles built pressure. The instability was presented as evidence the product was alive rather than as a manufacturing failure.

Howard and Rich Finkelstein brought a bottle to Michael Koschitz, who had been manufacturing liquids since 2004 and running his own facility since 2012.

It took him about ten seconds to realize something was wrong. The labeling wasn’t compliant. The bottle wasn’t properly sealed, and the seal could be lifted off without breaking it. The pH was wrong.

They had the people to build a company around it. What they didn’t have was a formula, and Michael knew he wasn’t the one who could write it.

Everything that makes a liquid stable is designed to kill what’s in it

Preservatives. Alcohol. Hot fill. Pasteurizing the finished product.

Those are the tools. All four work by killing whatever is living in the bottle, which is the entire point of a shelf-stable liquid and the exact opposite of what this product needed.

So the standard playbook wasn’t a starting point. It was a list of things we couldn’t do.

Gloved hands tipping a sachet of pale culture powder into a steel tank of green pressed juice
Opening capsules into juice. The first attempt, and it did not hold.

The first attempt was somebody opening capsules into juice

He had worked at the original company and believed he knew how it was made. His method was to buy probiotic capsules, open them, and stir the contents into juice.

No testing of what was in the capsule. No control over the result. No path to making the same thing twice.

We called it Floravia. It went nowhere.

The second attempt lasted years

We brought in a credentialed food scientist who understood the chemistry and nothing about manufacturing or formulation.

Years went into that. A company built, people hired, sample after sample failing.

A glass bottle of green juice bursting, shattered glass and juice thrown outward
Living cultures keep fermenting. That is what they did to the glass.

Then a bottle exploded in the office

We thought the formula was locked. We were preparing to bring in an investment group.

A heavy glass bottle had been left in a room. It went off loudly enough to be heard across the building. Glass everywhere, the walls green, part of the window blinds taken off.

Nobody was in the room. Somebody easily could have been.

What made it worse was how normal it had become. Lids bulging a little. Some gas. Burp the bottle and carry on. Nobody had decided to ignore a dangerous problem. It had just gradually stopped looking like one.

The first time it nearly ended

After that we stopped. Four years in, and we had concluded that a stable version of this product might not be possible.

There was no formula. Not a bad one. None. The whole idea was about to die before anything had been made.

A hand writing in a graph paper notebook on a steel bench, a pen, shallow covered dishes and a glass jar around it.

Then somebody found the actual problem

That was when Dr. Reza Kamarei came into our life. He looked at the formulation and found what years of adjustment had been working around.

There was an organism in the blend that didn’t belong there.

Everything else had been a symptom. Remove it, rebuild the blend properly, and the product behaved, almost immediately. That formulation is what’s in the bottle today.

The juice, it turned out, had never been the problem.

Pale green juice running across a wet plant floor into a stainless steel drain.

The second time it nearly ended

With the formulation settled, the next problem was volume. A pharmaceutical manufacturer, the most controlled and heavily regulated kind of facility there is, said they could make it at scale.

They made about seven batches. Every one failed.

We had assumed that once the formula was right, making it would be the easy part. It isn’t. Big equipment means long runs, long exposure, and more of everything you’re trying to keep out. This product cannot be made in large volume. It has to be small batch, in a tightly controlled environment, or it simply can’t be made properly.

That lesson cost seven batches, over a hundred thousand dollars in components, materials and labor, and nearly the company itself. It’s why we make it the way we do.

Six bottles of Doctor's Biome Gut Health standing in a row on a refrigerator door shelf, condensation on the glass.

Why the fridge

Once it was stable, we had a choice about the cold chain.

The cultures keep going either way. But as they feed, prebiotics are consumed, postbiotics are generated, and the flavor changes along with them.

That sequence is the whole idea

Left warm for long enough, it turns sour enough that you wouldn’t want to drink it.

This is a food. A juice shot that stops tasting good is a failed product no matter how well the cultures are doing. Cold slows the whole thing down so what you drink is what we made.

Shipping cold costs about five times what shipping ambient costs. We stopped treating that as a problem to solve.

Green juice pouring from a cold amber bottle into a glass, against a deep green ground.

What we actually make

Two ounces of pressed fruit and vegetable juice with fifteen strains of live cultures in it. Cold, just the right amount of sweet and a little tart, no aftertaste.

It’s made in small batches, in a facility that doesn’t make fifty other things, from juice that arrives tested and clean. Every batch is counted by an independent laboratory.

The science behind it

See both blends